- Immune regulation
- T-cell exhaustion
- Dendritic cell biology
- Anti-viral immunity
- Vaccine immunology
- Vaccine carriers/adjuvants
- Therapeutic antibodies
- Advanced genome and proteome studies
The main interests of Vaccine Technology Laboratory (VTL) can be divided into two main titles; the investigation of the regulation of immune responses and the development of novel immunotherapeutic methods.
Mechanisms of T-cell response and T-cell exhaustion are important points influencing the course of pathology in chronic infections and cancers. Within the scope of this problem, VTL focuses on the molecular effects on inhibitory receptors (PD-1 and its ligands) that play roles in dendritic cell biology (interaction between HBV-dendritic cell in particular), regulating T-cell response and in T-cell exhaustion. VTL has been working on Hepatitis B virus (HBV) which still causes medical problems in our country. In this field, the molecular effects of therapeutic immunizations for the viral infection and the related anti-viral immune response in HBV-transgenic mouse model (developed at our Institute) are investigated. Next generation genome/transcriptome sequencing with advanced proteomic techniques are also used in immunological studies besides conventional immunologic techniques.
The aim of this laboratory is to move to large scale projects through application of hypothesis based experimental studies integrated with omic technologies in human immunology. Researchers with PhD degree in VTL have expertise on mechanisms of follicular dendritic cells, allergy, anti-viral cell immune response and differentiation of immune cells. The development of monoclonal antibodies against infectious agents is another area of expertise of the laboratory and a significant number of monoclonal antibodies against various antigens have been produced in related projects.